Kunihisa Miwa, a Japanese ME/CFS researcher, has been on something of a role. Through no less than five studies he pioneered the small heart findings in chronic fatigue syndrome (ME/CFS). Systrom basically validated Miwa's finding in his large study of people with unexplained exercise intolerance - some of whom had ME/CFS.
Miwa appears to be something of a lone wolf; his ME/CFS studies were either authored just by him or by one other person. Miwa may not be working with a lot of researchers, but he's certainly up to date; he refers to ME/CFS as ME in this and other papers, and the patients in this study had to meet not the Canadian Consensus Criteria, but the International Consensus Criteria developed in 2011.
Miwa recognized that the small hearts he found in his chronic fatigue syndrome (ME/CFS) patients were likely due not to some defect but to reduced blood flows. If the heart, like any other muscle, doesn't work out it won't grow, and the heart needs blood, and lots of it, to work itself into shape.
In this study (ME/CFS=8, HC=5) people Miwa examined some factors - renin (plasma renin enzymatic activity), aldosterone and antidiuretic hormone (ADH) - that affect blood volume. He also also did an echocardiograph and examined the effects of desmopressin - an ADH replacement - to see if it helped.
Results
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